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Research in the Hund Lab addresses the regulation of cardiac ion channels and cell excitability with the overall objective of understanding human cardiac arrhythmia and disease mechanisms. Studies in the lab span cardiac cell biology and electrophysiology to computational biology and mathematical modeling to murine models of cardiac arrhythmia (in vivo and ex vivo) and heart failure. A major focus of our research is the role of the cytoskeletal protein betaIV-spectrin in organizing ion channel macromolecular complexes at the cardiomyocyte intercalated disc to regulate cell excitability. Our work has received support from the National Institutes of Health, American Heart Association, Gilead Sciences Research Scholars Program, the James S. McDonnell Foundation.