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Publications

 

Pubmed

Google scholar profile for Dr. Hund

Selected publications

Onal B, Gratz D, Hund TJ. Ca2+/calmodulin-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling and excitability: a mathematical modeling study. Am J Physiol Heart Circ Physiol. 2017;313:H1227-H1239.

Onal B, Gratz D, Hund T. LongQt: A cardiac electrophysiology simulation platform. MethodsX. 2016; 3:589-599.

Unudurthi SD, Wu X, Qian L, Amari F, Onal B, Li N, Makara MA, Smith SA, Snyder J, Fedorov VV, Coppola V, Anderson ME, Mohler PJ, Hund TJ. The two-pore K+ channel TREK-1 regulates sinoatrial node membrane excitability. J Am Heart Assoc. 2016; 5:e002865.

Glynn P, Musa H, Wu X, Unudurthi SD, Little S, Qian L, Wright PJ, Radwanski PB, Gyorke S, Mohler PJ, Hund TJ. Voltage-gated sodium channel phosphorylation at Ser571 regulates late current, arrhythmia, and cardiac function in vivo. Circulation. 2015;132:567-577.

Hund TJ, Snyder JS, Wu X, Glynn P, Koval OM, Onal B, Leymaster ND, Unudurthi SD, Curran J, Camardo C, Wright PJ, Binkley PF, Anderson ME, Mohler PJ. BetaIV-spectrin regulates TREK-1 membrane targeting in heart. Cardiovasc Res. 2014; 102:166-75.

Glynn P, Onal B, Hund TJ. Cycle length restitution in sinoatrial node cells: A theory for understanding spontaneous action potential dynamics. PLoS ONE. 2014; 9:e89049.

Onal B, Unudurthi SD, Hund TJ. Modeling CaMKII in cardiac physiology: From molecule to tissue. Front Pharmacol. 2014; 5:9.

Unudurthi SD, Wolf RM, Hund TJ. Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking. Front Physiol. 2014; 5:446.

Wolf RM, Glynn P, Hashemi S, Zarei K, Mitchell CC, Anderson ME, Mohler PJ, Hund TJ. Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: A computational analysis. Am J Physiol Heart and Circ Physiol. 2013; 304:H1253-66.

Luo M, Guan X, Di L, Kutschke W, Gao Z, Yang J, Luczak ED, Glynn P, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Sossalla S, Maier LS, Efimov I, Hund TJ, Anderson ME. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013; 123:1262-74.

Koval OM, Snyder JS, Wolf RM, Pavlovicz RE, Glynn P, Curran J, Leymaster ND, Dun W, Wright PJ, Cardona N, Qian L, Mitchell CC, Boyden PA, Binkley PF, Li C, Anderson ME, Mohler PJ, and Hund TJ. Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation. 2012; 126:2084-2094.

Swaminathan PD, Purohit AS, Hund TJ, and Anderson ME. CaM Kinases: Linking heart failure and arrhythmias. Circ Res. 2012;110:1661-1677.

Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He JB, Luczak ED, Joiner MA, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, and Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction. J Clin Invest. 2011; 121:3277-88.

Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, and Mohler PJ. A betaIV spectrin/CaMKII signaling complex is essential for membrane excitability in mice. J Clin Invest. 2010;120:3508-19.

Wolf RM, Mitchell CC, Christensen MD, Mohler PJ, and Hund TJ. Defining new insight into atypical arrhythmia: a computational model of ankyrin-B-syndrome. Am J Physiol Heart Circ Physiol. 2010; 299:H1505-H1514.

Christensen MD, Dun W, Boyden PA, Anderson ME, Mohler PJ, and Hund TJ. Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis. PLoS Comput Biol. 2009; 5:e1000583.

Hund TJ, Wright P, Dun W, Snyder JS, Boyden PA, and Mohler PJ. Regulation of ankyrin-B-based targeting pathway following myocardial infarction. Cardiovasc Res. 2009; 81:742-749.

Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, and Y Rudy. Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling. J Mol Cell Cardiol. 2008; 45:420-8.

Hund TJ and Y Rudy. Rate dependence and regulation of the action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 2004; 110:3168-3174.