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Thomas Hund

  • Professor, Biomedical Engineering
  • 333 W. 10th Ave
    Graves 5078
    Columbus, OH 43210
  • 614-292-0755

Honors

  • 20170301

    Lumley Research Award.

  • 20160301

    Distinguished Undergraduate Research Mentor, Nominee.

  • 20150901

    Melissa G. Piper Distinguished Mentor Award.

  • 20140401

    Herman R. Weed Excellence in Teaching Award.

  • 20130901

    Complex Systems Scholar.

  • 20110101

    Research Scholar in Cardiovascular Disease.

  • 20090901

    NIH Pathway to Independence Award (K99/R00).

  • 20080101

    Early-Career Authors Prize.

  • 20060401

    NIH Ruth L. Kirchstein National Research Service Award (F32).

Chapters

2012

  • 2012. "Principles of Cellular Architecture and Physiology with Applications in Electrophysiology." In Electrophysiological Disorders of the Heart. 2nd Edition, edited by Saksena and Camm,

2011

  • 2011. "Calmodulin kinase II regulation of heart rhythm and disase." In Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation, and Clinical Implications, edited by Tripathi ON, Ravens U, and Sanguinetti MC,

Journal Articles

2016

  • Smith, Sakima, A; Hughes, Langston; Kline, Crystal, F; Kempton, Amber; Dorn, Lisa; Curran, Jerry; Makara, Michael; Webb, Tyler; Wright, Patrick; Voigt, Niels; Binkley, Philip, F; Janssen, Paul,M,L;Kilic, Ahmet; Carnes, Cynthia, A; Dobrev, Dobromir; Rasband, Matthew; Hund, Thomas, J; Mohler, Peter, J, 2016, "Dysfunction of the betaII spectrin-based pathway in human heart failure." AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 310, H1583-91 - H1583-91.
  • Onal,Birce; Hund,Thomas,J, 2016, "Physiological variability and atrial fibrillation therapy: Insights from population-based mathematical modeling.." Heart rhythm 13, 2366-2367 - 2366-2367.

2015

  • Smith,Sakima,A; Sturm,Amy,C; Curran,Jerry; Kline,Crystal,F; Little,Sean,C; Bonilla,Ingrid,M; Long,Victor,P; Makara,Michael; Polina,Iuliia; Hughes,Langston,D; Webb,Tyler,R; Wei,Zhiyi; Wright,Patrick; Voigt,Niels; Bhakta,Deepak; Spoonamore,Katherine,G; Zhang,Chuansheng; Weiss,Raul; Binkley,Philip,F; Janssen,Paul,M; Kilic,Ahmet; Higgins,Robert,S; Sun,Mingzhai; Ma,Jianjie; Dobrev,Dobromir; Zhang,Mingjie; Carnes,Cynthia,A; Vatta,Matteo; Rasband,Matthew,N; Hund,Thomas,J; Mohler,Peter,J, 2015, "Dysfunction in the beta II Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia." CIRCULATION 131, no. 8, 695-U72 - 695-U72.
  • Musa,Hassan; Kline,Crystal,F; Sturm,Amy,C; Murphy,Nathaniel; Adelman,Sara; Wang,Chaojian; Yan,Haidun; Johnson,Benjamin,L; Csepe,Thomas,A; Kilic,Ahmet; Higgins,Robert,SD; Janssen,Paul,ML; Fedorov,Vadim,V; Weiss,Raul; Salazar,Christina; Hund,Thomas,J; Pitt,Geoffrey,S; Mohler,Peter,J, 2015, "SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, no. 40, 12528-12533 - 12528-12533.

2013

  • DeGrande,Sean,T; Little,Sean,C; Nixon,Derek,J; Wright,Patrick; Snyder,Jedidiah; Dun,Wen; Murphy,Nathaniel; Kilic,Ahmet; Higgins,Robert; Binkley,Philip,F; Boyden,Penelope,A; Carnes,Cynthia,A; Anderson,Mark,E; Hund,Thomas,J; Mohler,Peter,J, 2013, "Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 288, no. 2, 1032-1046 - 1032-1046.

2012

  • Koval,Olha,M; Snyder,Jedidiah,S; Wolf,Roseanne,M; Pavlovicz,Ryan,E; Glynn,Patric; Curran,Jerry; Leymaster,Nicholas,D; Dun,Wen; Wright,Patrick,J; Cardona,Natalia; Qian,Lan; Mitchell,Colleen,C; Boyden,Penelope,A; Binkley,Philip,F; Li,Chenglong; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2012, "Ca2+/Calmodulin-Dependent Protein Kinase II-Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease.." Circulation 126, no. 17, 2084-2094 - 2084-2094.

Presentations

  • "Defining novel mechanisms for regulation of cardiac excitability and function." 2016, Presented at Washington University in St. Louis, Department of Biomedical Engineering,
  • "Regulation of the late sodium current by CaMKII." 2016, Presented at Heart Rhythm Society's 37th Annual Scientific Sessions,
  • "Automaticity and cardiac pacemaking: A computational analysis." 2013, Presented at Heart Rhythm Society's 34th Annual Scientific Sessions,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2012, Presented at Big 10 Seminar Series,
  • "Integrating in vivo, in vitro, and in silico approaches to define excitable cell disease." 2011, Presented at Annual Meeting of the Central Society for Clinical Research,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2012, Presented at Cardiac Bioelectricity and Arrhythmia Center Seminar,
  • "The role of calcium in ischemia and heart failure." 2007, Presented at Gordon Research Conference on Cardiac Arrhythmia Mechanisms,
  • "Excitable cell disease from in silico to in vivo." 2013, Presented at Case Western Reserve University BME Seminar,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2011, Presented at 3rd Annual Leducq Meeting of the Transatlantic CaMKII Alliance,
  • "Ankyrin-B dysfunction and arrhythmias." 2012, Presented at Gordon Research Conference on Regulatory Mechanisms,
  • "CaMKII-dependent Na+ channel regulation: Modeling studies." 2014, Presented at UC Davis Cardiovascular Symposium 2014,
  • "Mathematical modeling of mitochondria." 2014, Presented at Heart Rhythm Society's 35th Annual Scientific Sessions,
  • "Modeling for non-modelers." 2014, Presented at Heart Rhythm Society's 35th Annual Scientific Sessions,
  • "Modeling intercellular coupling in post-MI arrhythmias." 2010, Presented at American Heart Association Scientific Sessions,
  • "Cycle length restitution and spontaneous action potential dynamics in sinoatrial node disease." 2014, Presented at Biomedical Engineering Society 2014 Annual Meeting,
  • "Defining novel mechanisms underlying atrial arrhythmias: Insights from computational studies." 2016, Presented at Advanced Biomedical Modeling: From Image to Simulation Seminar and Workshop,
  • "Defining novel mechanisms for regulation of cardiac excitability." 2016, Presented at Purdue University Weldon School of Biomedical Engineering Distinguished Seminar Series,
  • "Sodium channel scaffolds." 2015, Presented at American Heart Association Scientific Sessions,
  • "Protein phosphatae post-translational regulation in heart disease." 2015, Presented at American Heart Association Scientific Sessions,

Papers in Proceedings

2014

  • Curran, J.; Little, S.; Makara, M.; Wu, X. et al. "EHD3 Mediates Integral Membrane Protein Trafficking and Maintain Electrical Excitability and Adrenergic Responsiveness in the Heart." (1 2014).
  • Curran, J.; Little, S.; Makara, M.; Wu, X. et al. "EHD3 Mediates Integral Membrane Protein Trafficking and Maintain Electrical Excitability and Adrenergic Responsiveness in the Heart." in 58th Annual Meeting of the Biophysical-Society. (1 2014).
  • Curran,Jerry; Little,Sean; Makara,Mike; Wu,Xianqiong; Polina,Iulia; Wright,Patrick,J; Liu,Bin; Gyorke,Sandor; Hund,Thomas,J; Mohler,Peter,J "EHD3 Mediates Integral Membrane Protein Trafficking and Maintain Electrical Excitability and Adrenergic Responsiveness in the Heart." in 58th Annual Meeting of the Biophysical-Society. (1 2014).

2013

  • Wolf,Roseanne,M; Glynn,Patric; Hashemi,Seyed; Zarei,Keyan; Mitchell,Colleen; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J "Atrial Fibrillation and Sinus Node Dysfunction in Human Ankyrin-B Syndrome: A Computational Analysis." in 57th Annual Meeting of the Biophysical-Society. (1 2013).
  • Wolf, R.M.; Glynn, P.; Hashemi, S.; Zarei, K. et al. "Atrial Fibrillation and Sinus Node Dysfunction in Human Ankyrin-B Syndrome: A Computational Analysis." in 57th Annual Meeting of the Biophysical-Society. (1 2013).
  • Wolf, R.M.; Glynn, P.; Hashemi, S.; Zarei, K. et al. "Atrial Fibrillation and Sinus Node Dysfunction in Human Ankyrin-B Syndrome: A Computational Analysis." (1 2013).

2012

  • Dybkova,N; Wagner,S; Backs,J; Mohler,P; Hund,T; Maier,L "CaMKII-dependent late INa and cardiac Na channel phosphorylation are disturbed by tubulin polymerization." in Congress of the European-Society-of-Cardiology (ESC). (8 2012).

2010

  • Li, J.; Kline, C.F.; Hund, T.J.; Anderson, M.E. et al. "Ankyrin-b-Based Protein Complex Regulates the Ischemic Response in Heart." (11 2010).
  • Li, J.; Kline, C.F.; Hund, T.J.; Anderson, M.E. et al. "Ankyrin-b-Based Protein Complex Regulates the Ischemic Response in Heart." (11 2010).
  • Li,Jingdong; Kline,Crystal,F; Hund,Thomas,J; Anderson,Mark,E; Mohler,Peter,J "Ankyrin-B-Based Protein Complex Regulates the Ischemic Response in Heart." in American Heart Association Scientific Sessions. (11 2010).

2003

  • Hund, Thomas, J; Rudy,Yoram "Calcium regulation and cellular electrophysiology." in 25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society. (1 2003).
  • Hund, T.J.; Rudy, Y.; IEEE, "Calcium regulation and cellular electrophysiology." (1 2003).
  • Hund, T.J.; Rudy, Y. "Calcium Regulation and Cellular Electrophysiology." (12 2003).
  • Hund, T.J.; Rudy, Y. "Calcium regulation and cellular electrophysiology." in 25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society. (1 2003).

2002

  • Hund, T.J.; Rudy, Y. "Ca2+/calmodulin-dependent protein kinase underlies rate dependence of Ca2+ transient in a dynamic model of the ventricular action potential." (11 2002).
  • Hund, Thomas, J; Rudy,Yoram "Ca2+/calmodulin-dependent protein kinase underlies rate dependence of Ca2+ transient in a dynamic model of the ventricular action potential." in American-Heart-Association Abstracts From Scientific Sessions. (11 2002).
  • Hund, T.J.; Rudy, Y. "Ca2+/calmodulin-dependent protein kinase underlies rate dependence of Ca2+ transient in a dynamic model of the ventricular action potential." in American-Heart-Association Abstracts From Scientific Sessions. (11 2002).

2000

  • Hund, T.J.; Otani, N.F.; Rudy, Y. "Dynamics of action potential head-tail interaction during reentry in cardiac tissue theoretical study of ionic mechanisms.." (1 2000).
  • Hund, T.J.; Otani, N.F.; Rudy, Y. "Dynamics of action potential head-tail interaction during reentry in cardiac tissue theoretical study of ionic mechanisms.." (1 2000).
  • Hund,Thomas,J; Otani,Niels,F; Rudy,Yoram "Dynamics of action potential head-tail interaction during reentry in cardiac tissue theoretical study of ionic mechanisms.." (1 2000).

1999

  • Hund, T.J.; Rudy, Y. "Restitution of excitability and action potential duration in cardiac myocytes: Mechanistic investigation of memory effect.." (1 1999).
  • Hund,Thomas,J; Rudy,Yoram "Restitution of excitability and action potential duration in cardiac myocytes: Mechanistic investigation of memory effect.." (1 1999).
  • Hund, T.J.; Rudy, Y. "Restitution of excitability and action potential duration in cardiac myocytes: Mechanistic investigation of memory effect.." (1 1999).

Patents

  • Carnes, Cynthia; Hund, Thomas; Li, Pui-Kai "Tom; Li, Chenglong; Mohler, Peter. "PP2A Regulatory Subunit Modification in Disease."
  • Hund, Thomas and Mohler, Peter. "SCN5A mouse model."
  • Hund, Thomas and Mohler, Peter. "SCN5E mouse model."