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Thomas Hund

  • Professor, Biomedical Engineering
  • 333 W. 10th Ave
    Graves 5078
    Columbus, OH 43210
  • 614-292-0755

Honors

  • 20170301

    Lumley Research Award.

  • 20160301

    Distinguished Undergraduate Research Mentor, Nominee.

  • 20150901

    Melissa G. Piper Distinguished Mentor Award.

  • 20140401

    Herman R. Weed Excellence in Teaching Award.

  • 20130901

    Complex Systems Scholar.

  • 20110101

    Research Scholar in Cardiovascular Disease.

  • 20090901

    NIH Pathway to Independence Award (K99/R00).

  • 20080101

    Early-Career Authors Prize.

  • 20060401

    NIH Ruth L. Kirchstein National Research Service Award (F32).

Chapters

2012

  • 2012. "Principles of Cellular Architecture and Physiology with Applications in Electrophysiology." In Electrophysiological Disorders of the Heart. 2nd Edition, edited by Saksena and Camm,

2011

  • 2011. "Calmodulin kinase II regulation of heart rhythm and disase." In Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation, and Clinical Implications, edited by Tripathi ON, Ravens U, and Sanguinetti MC,

Journal Articles

2016

  • Onal,Birce; Hund,Thomas,J, 2016, "Physiological variability and atrial fibrillation therapy: Insights from population-based mathematical modeling.." Heart rhythm 13, 2366-2367 - 2366-2367.
  • Smith, Sakima, A; Hughes, Langston; Kline, Crystal, F; Kempton, Amber; Dorn, Lisa; Curran, Jerry; Makara, Michael; Webb, Tyler; Wright, Patrick; Voigt, Niels; Binkley, Philip, F; Janssen, Paul,M,L;Kilic, Ahmet; Carnes, Cynthia, A; Dobrev, Dobromir; Rasband, Matthew; Hund, Thomas, J; Mohler, Peter, J, 2016, "Dysfunction of the betaII spectrin-based pathway in human heart failure." AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 310, H1583-91 - H1583-91.
  • Birce, Onal; Gratz, Daniel; Hund, Thomas, 2016, "LongQt: A cardiac electrophysiology simulation platform." MethodsX 3, 589-599 - 589-599.

2015

  • Curran, J.; Musa, H.; Kline, C.F.; Makara, M.A. et al., 2015, "Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.." The Journal of biological chemistry 290, no. 19, 12210-12221 - 12210-12221.
  • Musa,Hassan; Kline,Crystal,F; Sturm,Amy,C; Murphy,Nathaniel; Adelman,Sara; Wang,Chaojian; Yan,Haidun; Johnson,Benjamin,L; Csepe,Thomas,A; Kilic,Ahmet; Higgins,Robert,SD; Janssen,Paul,ML; Fedorov,Vadim,V; Weiss,Raul; Salazar,Christina; Hund,Thomas,J; Pitt,Geoffrey,S; Mohler,Peter,J, 2015, "SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, no. 40, 12528-12533 - 12528-12533.
  • Smith,Sakima,A; Sturm,Amy,C; Curran,Jerry; Kline,Crystal,F; Little,Sean,C; Bonilla,Ingrid,M; Long,Victor,P; Makara,Michael; Polina,Iuliia; Hughes,Langston,D; Webb,Tyler,R; Wei,Zhiyi; Wright,Patrick; Voigt,Niels; Bhakta,Deepak; Spoonamore,Katherine,G; Zhang,Chuansheng; Weiss,Raul; Binkley,Philip,F; Janssen,Paul,M; Kilic,Ahmet; Higgins,Robert,S; Sun,Mingzhai; Ma,Jianjie; Dobrev,Dobromir; Zhang,Mingjie; Carnes,Cynthia,A; Vatta,Matteo; Rasband,Matthew,N; Hund,Thomas,J; Mohler,Peter,J, 2015, "Dysfunction in the beta II Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia." CIRCULATION 131, no. 8, 695-U72 - 695-U72.
  • RadwaƄski, P.B.; Brunello, L.; Veeraraghavan, R.; Ho, H-T. et al., 2015, "Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.." Cardiovascular research 106, no. 1, 143-152 - 143-152.

2014

  • Kline, C.F.; Scott, J.; Curran, J.; Hund, T.J. et al., 2014, "Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.." The Journal of biological chemistry 289, no. 8, 5285-5295 - 5285-5295.
  • Glynn, P.; Unudurthi, S.D.; Hund, T.J., 2014, "Mathematical modeling of physiological systems: an essential tool for discovery.." Life sciences 111, no. 1-2, 1-5 - 1-5.
  • Hund, T.J.; Mohler, P.J., 2014, "Nav channel complex heterogeneity: new targets for the treatment of arrhythmia?." Circulation 130, no. 2, 132-134 - 132-134.
  • Curran, J.; Makara, M.A.; Little, S.C.; Musa, H. et al., 2014, "EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology.." Circulation research 115, no. 1, 68-78 - 68-78.

2013

  • DeGrande,Sean,T; Little,Sean,C; Nixon,Derek,J; Wright,Patrick; Snyder,Jedidiah; Dun,Wen; Murphy,Nathaniel; Kilic,Ahmet; Higgins,Robert; Binkley,Philip,F; Boyden,Penelope,A; Carnes,Cynthia,A; Anderson,Mark,E; Hund,Thomas,J; Mohler,Peter,J, 2013, "Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 288, no. 2, 1032-1046 - 1032-1046.
  • Wolf, R.M.; Glynn, P.; Hashemi, S.; Zarei, K. et al., 2013, "Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 304, no. 9, H1253-H1266 - H1253-H1266.
  • Gao, Z.; Rasmussen, T.P.; Li, Y.; Kutschke, W. et al., 2013, "Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.." Circulation research 112, no. 2, 309-317 - 309-317.
  • Noorman, M.; Hakim, S.; Kessler, E.; Groeneweg, J.A. et al., 2013, "Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.." Heart rhythm 10, no. 3, 412-419 - 412-419.

2012

  • Jansen, J.A.; Noorman, M.; Musa, H.; Stein, M. et al., 2012, "Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice." HEART RHYTHM 9, no. 4, 600-607 - 600-607.
  • Swaminathan, P.D.; Purohit, A.; Hund, T.J.; Anderson, M.E., 2012, "Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias.." Circulation research 110, no. 12, 1661-1677 - 1661-1677.
  • Smith, S.; Curran, J.; Hund, T.J.; Mohler, P.J., 2012, "Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death.." Frontiers in physiology 3, 122 - 122.
  • Gudmundsson, H.; Curran, J.; Kashef, F.; Snyder, J.S. et al., 2012, "Differential regulation of EHD3 in human and mammalian heart failure.." Journal of molecular and cellular cardiology 52, no. 5, 1183-1190 - 1183-1190.
  • Koval,Olha,M; Snyder,Jedidiah,S; Wolf,Roseanne,M; Pavlovicz,Ryan,E; Glynn,Patric; Curran,Jerry; Leymaster,Nicholas,D; Dun,Wen; Wright,Patrick,J; Cardona,Natalia; Qian,Lan; Mitchell,Colleen,C; Boyden,Penelope,A; Binkley,Philip,F; Li,Chenglong; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2012, "Ca2+/Calmodulin-Dependent Protein Kinase II-Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease.." Circulation 126, no. 17, 2084-2094 - 2084-2094.

2011

  • Besse, I.M.; Mitchell, C.C.; Hund, T.J.; Shibata, E.F., 2011, "A computational investigation of cardiac caveolae as a source of persistent sodium current.." Frontiers in Physiology 2, 87 - 87.
  • Gao, Z.; Singh, M.V.; Hall, D.D.; Koval, O.M. et al., 2011, "Catecholamine-independent heart rate increases require Ca2+/calmodulin-dependent protein kinase II.." Circulation. Arrhythmia and electrophysiology 4, no. 3, 379-387 - 379-387.

2010

  • Gudmundsson, H.; Hund, T.J.; Wright, P.J.; Kline, C.F. et al., 2010, "EH Domain Proteins Regulate Cardiac Membrane Protein Targeting." CIRCULATION RESEARCH 107, no. 1, 84-U175 - 84-U175.

2009

  • Decker, K.F.; Heijman, J.; Silva, J.R.; Hund, T.J. et al., 2009, "Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium.." American journal of physiology. Heart and circulatory physiology 296, no. 4, H1017-H1026 - H1017-H1026.
  • Hund, T.J.; Wright, P.J.; Dun, W.; Snyder, J.S. et al., 2009, "Regulation of the ankyrin-B-based targeting pathway following myocardial infarction." CARDIOVASCULAR RESEARCH 81, no. 4, 742-749 - 742-749.
  • Christensen, M.D.; Dun, W.; Boyden, P.A.; Anderson, M.E. et al., 2009, "Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.." PLoS computational biology 5, no. 12, e1000583 - e1000583.

2008

  • Thiel, W.H.; Chen, B.; Hund, T.J.; Koval, O.M. et al., 2008, "Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.." Circulation 118, no. 22, 2225-2234 - 2225-2234.

Presentations

  • "Defining novel mechanisms for regulation of cardiac excitability and function." 2016, Presented at Washington University in St. Louis, Department of Biomedical Engineering,
  • "Regulation of the late sodium current by CaMKII." 2016, Presented at Heart Rhythm Society's 37th Annual Scientific Sessions,
  • "Automaticity and cardiac pacemaking: A computational analysis." 2013, Presented at Heart Rhythm Society's 34th Annual Scientific Sessions,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2012, Presented at Big 10 Seminar Series,
  • "Integrating in vivo, in vitro, and in silico approaches to define excitable cell disease." 2011, Presented at Annual Meeting of the Central Society for Clinical Research,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2012, Presented at Cardiac Bioelectricity and Arrhythmia Center Seminar,
  • "The role of calcium in ischemia and heart failure." 2007, Presented at Gordon Research Conference on Cardiac Arrhythmia Mechanisms,
  • "Excitable cell disease from in silico to in vivo." 2013, Presented at Case Western Reserve University BME Seminar,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2011, Presented at 3rd Annual Leducq Meeting of the Transatlantic CaMKII Alliance,
  • "Ankyrin-B dysfunction and arrhythmias." 2012, Presented at Gordon Research Conference on Regulatory Mechanisms,
  • "CaMKII-dependent Na+ channel regulation: Modeling studies." 2014, Presented at UC Davis Cardiovascular Symposium 2014,
  • "Mathematical modeling of mitochondria." 2014, Presented at Heart Rhythm Society's 35th Annual Scientific Sessions,
  • "Modeling for non-modelers." 2014, Presented at Heart Rhythm Society's 35th Annual Scientific Sessions,
  • "Modeling intercellular coupling in post-MI arrhythmias." 2010, Presented at American Heart Association Scientific Sessions,
  • "Cycle length restitution and spontaneous action potential dynamics in sinoatrial node disease." 2014, Presented at Biomedical Engineering Society 2014 Annual Meeting,
  • "Defining novel mechanisms underlying atrial arrhythmias: Insights from computational studies." 2016, Presented at Advanced Biomedical Modeling: From Image to Simulation Seminar and Workshop,
  • "Defining novel mechanisms for regulation of cardiac excitability." 2016, Presented at Purdue University Weldon School of Biomedical Engineering Distinguished Seminar Series,
  • "Sodium channel scaffolds." 2015, Presented at American Heart Association Scientific Sessions,
  • "Protein phosphatae post-translational regulation in heart disease." 2015, Presented at American Heart Association Scientific Sessions,

Papers in Proceedings

2012

  • Dybkova,N; Wagner,S; Backs,J; Mohler,P; Hund,T; Maier,L "CaMKII-dependent late INa and cardiac Na channel phosphorylation are disturbed by tubulin polymerization." in Congress of the European-Society-of-Cardiology (ESC). (8 2012).

Patents

  • Carnes, Cynthia; Hund, Thomas; Li, Pui-Kai "Tom; Li, Chenglong; Mohler, Peter. "PP2A Regulatory Subunit Modification in Disease."
  • Hund, Thomas and Mohler, Peter. "SCN5A mouse model."
  • Hund, Thomas and Mohler, Peter. "SCN5E mouse model."