Cardiac pacemaking mechanisms
The sinoatrial node is collection of specialized cells in the right atrium, responsible for controlling the normal heart rhythm. Sinoatrial node dysfunction, characterized by clinical signs of bradycardia, sinus pause or arrest, and supraventricular arrhythmia, is common in elderly but may be observed at any age due to a host of factors. The Hund lab has utilized an integrative approach to identify cell and tissue level factors important for synchronization of spontaneous sinoatrial node activity.
Luo M, Guan X, Di L, Kutschke W, Gao Z, Yang J, Luczak ED, Glynn P, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Sossalla S, Maier LS, Efimov I, Hund TJ, Anderson ME. Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013; 123:1262-74. PMCID: PMC3673230.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He JB, Luczak ED, Joiner MA, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, and Anderson ME. Oxidized CaMKII causes sinus node dysfunction. J Clin Invest. 2011; 121:3277-88. PMCID: PMC3223923. co-corresponding author.
Wolf RM, Glynn P, Hashemi S, Zarei K, Mitchell CC, Anderson ME, Mohler PJ, and Hund TJ. Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: A computational analysis. Am J Physiol Heart Circ Physiol. 2013; 304:H1253-66. PMCID: PMC3652094. corresponding author.
Glynn P, Onal B, Hund TJ. Cycle length restitution in sinoatrial node cells: A theory for understanding spontaneous action potential dynamics. PLoS ONE. 2014; 9:e89049. PMCID:PMC3923067.
Unudurthi SD, Wu X, Qian L, Amari F, Onal B, Li N, Makara MA, Smith SA, Snyder J, Fedorov VV, Coppola V, Anderson ME, Mohler PJ, Hund TJ. Two-pore K+ channel TREK-1 regulates sinoatrial node membrane excitability. J Am Heart Assoc. 2016; 5:e002865. PMCID:PMC4859279.